What is the difference between direct and indirect bilirubin

Hi I am 43 years old male. I did LFT on and on My LFT values are total Bilirubin 1. Sir , Got following results for my Mother 63 Yrs on 22 Nov : Indirect Bilurubin in above range , kindly advise :.

There is a mild increase in Bilirubin and indirect bilirubin. Please repeat only bilirubin and its fractions after one month and see the result.

I hope this may become normal. But sir , my doctor has put me on no-oil diet for next 10 days and asked to repeat test after that. I smoke weed at least 5 times a week. Then we re-did it 5. Should I be concerned with the increase in both the indirect but mostly the direct? Most doctors are not concerned at this point in time. I am nervous about BA. This may be physiologic jaundice.

It needs phototherapy. The only concern is that jaundice appears within 24 hours. Right now my son is one month old as of tomorrow. Direct has never gone above 1 on the four previous draws. We did it at a different lab this time. All liver tests including GGT are normal. What do you think? No jaundice, stools are still the correct color. My new born baby male having high direct bilirubin 3. It is good that direct bilirubin is increasing, which shows that the liver is working.

Also, give phototherapy. I am sure that the baby is under the supervision of a pediaarician. Those are abnormal numbers. What is the timeframe between the increases? My sons ALP was also elevated. Did you get a GGT level done? Good day Doctor, please help me out am on drug for hepatitis B. Total bilirubin is 0.

Direct is 0. Total bilirubin is 2. Your indirect bilirubin and total bilirubin are raised. Hemoglobin is also low. I will suggest you consult a physician for further workup. Good day, doctor! May I ask if what is the formula in the calculation of the Bilirubin Concentration of the unknown and Control? And can I ask for some examples of the computation?

You can solve this by knowing three values. Your total bilirubin and indirect bilirubin are raised. You need to work up to find the pathology or cause of the increased bilirubin. No doubt this is benign hyperbilirubinemia. Still, I will suggest consulting a physician.

Doctor, One month 10 days old with Total Bilirubin value at Currently running an antibiotic course of 7 days for ear infection. Feeding, peeing are normal. We have been advised by doctors to wait and retest again. Please advise. You have not told me when jaundice appears? I will also recommend checking bilirubin levels daily to avoid damage to the brain. Doctor, Jaundice was there during the first week, it became normal after a few sessions of photo therapy.

This is appeared again after almost 35 days after birth. The doctors have suggested breast milk jaundice. There is a condition of breast milk jaundice, I am sending you the CDC publication. Please read this for information. Thank you very much for your insight. Levels have come down. Very much appreciate your quick turnaround replies. Hi Doctor my total Bilirubin is 2. T SGPT is Your total bilirubin is raised.

It means there is no active liver cell disease necrosis. Your result is confusing to rule out congenital hyperbilirubinemia. It looks benign hyperbilirubinemia. It would help if you had further workup like ultrasound and repeat bilirubin total and direct, indirect.

Your bilirubin is raised, and SGPT is also mildly raised. You need to consult a physician for a workup and to reach the diagnosis. My bilrubin total is 1. Are in normal. Liver functions are normal, but lipid profile is abnormal. Cholesterol and triglycerides are raised. I think you need to control the lipid profile. Hi sir, I took blood test recently, my direct bilirubin is 0. Kindly help me is it dangerous? Since I am non-alcoholic non-smoker. Also, get a viral hepatitis profile. My elder brother bilirubin total is 1.

Please kindly help me is it dangerous?? Since he is non alcoholic non smeker. Please check his viral hepatitis markers. But sir his HBsAg report is non reactive. So is it dangerous? You Hemoglobin and RBC count are in the high range. It needs further workup and consultation by a physician.

My HBsAg report is non reactive. Please kindly help me sir is it dangerous? Please kindly help me is it dangerous? I hope you are nonalcoholic and not taking any medication.

You should also check the Hepatitis C virus. Very comprehensive read. I just got checked out as well and my total bilirubin was 0. The lab says normal values of direct bilirubin are 0. Is this something to check further? I Am 21 Years Old. I am having yellowish skin and eyes and dark urine and Pale Stools. No Other Symptoms. What kind Of Jaundice is this? Itching is a sign of obstructive jaundice. It would help if you had an ultrasound abdomen to rule out gall stone or any other cause of obstruction.

Respected Sir, My son 17 years old affected by Type 1 diabetes, finding bilirubin 1. SGOT Any advise for him. I think to check Hepatitis B and C. His enzymes are normal. No need to worry, and just do his every 3 to 6 months, his LFT liver function test. My doctor ignored the result and tells me about a probable Gilbert syndrome. He told me to stay calm. I will greatly appreciate your response and if I can definitely rest assured with these results.

Best regards from Argentina. Best regards! Thank you very much! So this is benign, mild hyperbilirubinemia. Just in routine, take more fruits, avoid alcohol intake and tobacco smoking. I took a blood test and my levels were 3. You have not mentioned age?. Anyhow your enzymes are normal, which shows no liver cells necrosis. There is indirect hyperbilirubinemia. It looks like benign hyperbilirubinemia. I will suggest a follow-up. I am male age 24 having billiribum total is 1. These values are the upper limit of liver functions.

There is mild injury going on in the liver. Are you taking any drugs? Indirect bilirubin is insoluble in water, and it is highly hydrophobic. Indirect bilirubin can cross the plasma membrane easily. The toxicity of indirect bilirubin is high, especially to the nervous system. Therefore, indirect bilirubin is converted to a more soluble, non-toxic form which is the conjugated form.

Indirect albumin is associated with albumin, which is the main transport protein for bilirubin. Increased level of indirect bilirubin in serum can be due to the several reasons such as increased RBC hemolysis Erythroblastosisfetalis , conditions such as sickle cell anaemia , hepatitis, cirrhosis and due to the effect of some drugs etc.

Direct and indirect bilirubin are the two forms of bilirubin in serum. They are measured as a part of the liver function test. Direct bilirubin is the more soluble, less toxic and is the conjugated form of bilirubin. Direct bilirubin is conjugated with glucuronic acid. Indirect bilirubin is the unconjugated form of bilirubin. It is highly toxic and is less soluble in water. Therefore, it is bound to albumin for transportation purposes.

Increased direct and indirect bilirubin levels indicate metabolic disorders and diseases associated with the liver. This is the difference between direct and indirect bilirubin. You can download PDF version of this article and use it for offline purposes as per citation note.

Available here 2. Indirect and direct bilirubin: origins, properties and metabolism. Available here. Samanthi Udayangani holds a B. Upvote 3 Views Followers 3. Write an Answer Register now or log in to answer. Bilirubin is a breakdown product of heme conjogated Upvote 5 Downvote 0 Reply 0. Upvote 4 Downvote 0 Reply 0. Upvote 3 Downvote 0 Reply 0. Upvote 1 Downvote 0 Reply 0. Conjugated "Direct" In the liver bilirubin is conjugated with glucuronic acid by the enzyme glucuronyltransferase , making it soluble in water.

Unconjugated bilirubin —when heme is released from hemoglobin, it is converted to unconjugated bilirubin. It is carried by proteins to the liver. Small amounts may be present in the blood. Conjugated bilirubin —formed in the liver when sugars are attached conjugated to bilirubin. It enters the bile and passes from the liver to the small intestines and is eventually eliminated in the stool.

Normally, no conjugated bilirubin is present in the blood. In newborns with jaundice, bilirubin is used to distinguish the causes of jaundice. In both physiologic jaundice of the newborn and hemolytic disease of the newborn , only unconjugated indirect bilirubin is increased. In much less common cases, damage to the newborn's liver from neonatal hepatitis and biliary atresia will increase conjugated direct bilirubin concentrations as well, often providing the first evidence that one of these less common conditions is present.

Upvote 0 Downvote 0 Reply 0. Answer added by Ghayas U din 1 year ago.